Laitteiden välisen yhteistyön soveltuvuus älypuhelimilla toteutettavaan sisätilapaikannukseen

A reliable indoor positioning service for smartphones is a service that is often requested. There are several competing technologies already available but a lot of basic research is still done on the subject. This thesis studies the applicability and technological possibilities of improving the performance of a positioning service using peer to peer collaboration. The Bluetooth low energy technology (BLE) offers a possibility to use peer to peer radio signal measurements with smartphones. This could be used to improve the performance of existing positioning algorithms if enough service users are in close proximity to each other. In this thesis a pedestrian simulation system was implemented to study the probability that two positioning service users are in close enough proximity to each other for BLE usage. The suitability of BLE as the collaboration technology was studied by implementing a particle filter based positioning system that uses BLE measurements to track a smartphone. Finally the collaborative BLE system was integrated on top of an existing geomagnetic tracking algorithm and the effect on the positioning performance was studied. It was concluded that the BLE as a technology is suitable for positioning use despite the large measurement uncertainty. BLE based collaboration is feasible in improving the positioning results provided that the basic positioning technology is reliable enough. The pedestrian simulations concluded that with realistic expected number of users in one building most sessions would not benefit from collaboration but it would still likely happen frequently.Luotettava sisätilapaikannuspalvelu on haluttu ominaisuus mobiilipalveluiden kehityksessä. Useita kilpailevia ratkaisuja on jo markkinoilla, mutta ongelman parissa tehdään vielä huomattavan paljon perustutkimusta. Tässä diplomityössä tutkitaan mahdollisuutta parantaa paikannusjärjestelmän toimintaa käyttäen vertaisyhteistyötä. Bluetooth low energy -teknologia (BLE) tarjoaa mahdollisuuden käyttää laitteiden välisiä radiosignaalimittauksia älypuhelimilla. Tätä voidaan mahdollisesti hyödyntää parantamaan olemassa olevien paikannusalgoritmien toimintaa, jos riittävästi käyttäjiä on riittävän lähellä toisiaan. Tässä diplomityössä toteutettiin ihmisjoukkojen liikettä sisätiloissa mallintava järjestelmä, jolla tutkittiin todennäköisyyttä, että kaksi paikannusjärjestelmän käyttäjää olisi riittävän lähellä toisiaan käyttääkseen BLE-radiomittauksia. BLE:n soveltuvuutta paikannusteknologiana tutkittiin toteuttamalla partikkelisuotimeen perustuva paikannusjärjestelmä, joka käyttää BLE-mittauksia älypuhelimen seuraamiseen. Lopuksi BLE mittausjärjestelmä integroitiin olemassa olevaan magneettikenttään perustuvaan paikannusalgoritmiin ja BLE-yhteistyön vaikutusta algoritmin toimintaan tutkittiin. Työ osoitti, että BLE on paikannuskäyttöön soveltuva teknologia suuresta mittausepävarmuudesta huolimatta. BLE-perusteinen yhteistyö paikannustuloksen parantamisessa on toimiva ratkaisu, mikäli varsinainen paikannusteknologia on riittävän luotettava. Realistisesti odotettavissa olevilla paikannuspalvelun käyttäjämäärillä BLE-yhteistyötä todennäköisesti tapahtuisi suhteellisen usein, vaikka suurin osa paikannussessioista ei pääsisikään hyötymään siitä

Identification of proprioceptive thalamocortical tracts in children : comparison of fMRI, MEG, and manual seeding of probabilistic tractography

Studying white matter connections with tractography is a promising approach to understand the development of different brain processes, such as proprioception. An emerging method is to use functional brain imaging to select the cortical seed points for tractography, which is considered to improve the functional relevance and validity of the studied connections. However, it is unknown whether different functional seeding methods affect the spatial and microstructural properties of the given white matter connection. Here, we compared functional magnetic resonance imaging, magnetoencephalography, and manual seeding of thalamocortical proprioceptive tracts for finger and ankle joints separately. We showed that all three seeding approaches resulted in robust thalamocortical tracts, even though there were significant differences in localization of the respective proprioceptive seed areas in the sensorimotor cortex, and in the microstructural properties of the obtained tracts. Our study shows that the selected functional or manual seeding approach might cause systematic biases to the studied thalamocortical tracts. This result may indicate that the obtained tracts represent different portions and features of the somatosensory system. Our findings highlight the challenges of studying proprioception in the developing brain and illustrate the need for using multimodal imaging to obtain a comprehensive view of the studied brain process.Peer reviewe

Stronger proprioceptive BOLD-responses in the somatosensory cortices reflect worse sensorimotor function in adolescents with and without cerebral palsy

Cerebral palsy (CP) is a motor disorder where the motor defects are partly due to impaired proprioception. We studied cortical proprioceptive responses and sensorimotor performance in adolescents with CP and their typically-developed (TD) peers. Passive joint movements were used to stimulate proprioceptors during functional magnetic resonance imaging (fMRI) session to quantify the proprioceptive responses whose associations to behavioral sensorimotor performance were also examined. Twenty-three TD (15 females, age: mean +/- standard deviation 14.2 +/- 2.4 years) and 18 CP (12 females, age: mean +/- standard deviation, 13.8 +/- 2.3 years; 12 hemiplegic, 6 diplegic) participants were included in this study. Participants' index fingers and ankles were separately stimulated at 3 Hz and 1 Hz respectively with pneumatic movement actuators. Regions-of-interest were used to quantify BOLD-responses from the primary sensorimotor (SM1) and secondary (SII) somatosensory cortices and were compared across the groups. Associations between responses strengths and sensorimotor performance measures were also examined. Proprioceptive responses were stronger for the individuals with CP compared to their TD peers in SM1 (p < 0.001) and SII (p < 0.05) cortices contralateral to their more affected index finger. The ankle responses yielded no significant differences between the groups. The CP group had worse sensorimotor performance for hands and feet (p < 0.001). Stronger responses to finger stimulation in the dominant SM1 (p < 0.001) and both dominant and non-dominant SII (p < 0.01, p < 0.001) cortices were associated with the worse hand sensorimotor performance across all participants. Worse hand function was associated with stronger cortical activation to the proprioceptive stimulation. This association was evident both in adolescents with CP and their typically-developed controls, thus it likely reflects both clinical factors and normal variation in the sensorimotor function. The specific mechanisms need to be clarified in future studies.Peer reviewe

Gating Patterns to Proprioceptive Stimulation in Various Cortical Areas : An MEG Study in Children and Adults using Spatial ICA

Proprioceptive paired-stimulus paradigm was used for 30 children (10-17 years) and 21 adult (25-45 years) volunteers in magnetoencephalography (MEG). Their right index finger was moved twice with 500-ms interval every 4 ± 25 s (repeated 100 times) using a pneumatic-movement actuator. Spatial-independent component analysis (ICA) was applied to identify stimulus-related components from MEG cortical responses. Clustering was used to identify spatiotemporally consistent components across subjects. We found a consistent primary response in the primary somatosensory (SI) cortex with similar gating ratios of 0.72 and 0.69 for the children and adults, respectively. Secondary responses with similar transient gating behavior were centered bilaterally in proximity of the lateral sulcus. Delayed and prolonged responses with strong gating were found in the frontal and parietal cortices possibly corresponding to larger processing network of somatosensory afference. No significant correlation between age and gating ratio was found. We confirmed that cortical gating to proprioceptive stimuli is comparable to other somatosensory and auditory domains, and between children and adults. Gating occurred broadly beyond SI cortex. Spatial ICA revealed several consistent response patterns in various cortical regions which would have been challenging to detect with more commonly applied equivalent current dipole or distributed source estimates.peerReviewe

More comprehensive proprioceptive stimulation of the hand amplifies its cortical processing

Corticokinematic coherence (CKC) quantifies the phase coupling between limb kinematics and cortical neurophysiological signals reflecting proprioceptive feedback to the primary sensorimotor (SM1) cortex. We studied whether the CKC strength or cortical source location differs between proprioceptive stimulation (i.e., actuator-evoked movements) of right-hand digits (index, middle, ring and little). Twenty-one volunteers participated in magnetoencephalography measurements during which three conditions were tested: (1) simultaneous stimulation of all four fingers at the same frequency, (2) stimulation of each finger separately at the same frequency and (3) simultaneous stimulation of the fingers at finger-specific frequencies. CKC was computed between MEG responses and accelerations of the fingers recorded with three-axis accelerometers. CKC was stronger (p < 0.003) for the simultaneous (0.52 ± 0.02) than separate (0.45 ± 0.02) stimulation at the same frequency. Furthermore, CKC was weaker (p < 0.03) for the simultaneous stimulation at the finger-specific frequencies (0.38 ± 0.02) than for the separate stimulation. CKC source locations of the fingers were concentrated in the hand region of the SM1 cortex and did not follow consistent finger-specific somatotopic order. Our results indicate that that proprioceptive afference from the fingers is processed in partly overlapping cortical neuronal circuits, which was demonstrated by the modulation of the finger specific CKC strengths due to proprioceptive afference arising from simultaneous stimulation of the other fingers of the same hand as well as overlapping cortical source locations. Finally, comprehensive simultaneous proprioceptive stimulation of the hand would optimize functional cortical mapping to pinpoint the hand region, e.g., prior brain surgery.peerReviewe

Cortical proprioceptive processing is altered in children with diplegic cerebral palsy

Children with cerebral palsy (CP) have various motor impairments, but less is known about the processing deficits of the somatosensory afference, especially in the proprioceptive domain. Proprioception (“the movement sense”) is behaviorally impaired primarily in the more affected hand of children with CP1,2 and bilaterally in the lower limbs2 . There are no prior studies quantifying the cortical proprioceptive processing in CP, but hand representation area is diminished to tactile stimuli in hemiplegic CP3 and the primary cortical response to tibial nerve stimulation is reduced in diplegic CP4.Peer reviewe

Cortical proprioceptive processing is altered in children with diplegic cerebral palsy

Children with cerebral palsy (CP) have various motor impairments, but less is known about the processing deficits of the somatosensory afference, especially in the proprioceptive domain. Proprioception (“the movement sense”) is behaviorally impaired primarily in the more affected hand of children with CP1,2 and bilaterally in the lower limbs2 . There are no prior studies quantifying the cortical proprioceptive processing in CP, but hand representation area is diminished to tactile stimuli in hemiplegic CP3 and the primary cortical response to tibial nerve stimulation is reduced in diplegic CP4nonPeerReviewe

Altered corpus callosum structure in adolescents with cerebral palsy : connection to gait and balance

Cerebral palsy (CP) is the most common motor disorder in childhood. Recent studies in children with CP have associated weakened sensorimotor performance with impairments in the major brain white-matter (WM) structure, corpus callosum (CC). However, the relationship between CC structure and lower extremity performance, specifcally gait and balance, remains unknown. This study investigated the transcallosal WM structure and lower limb motor stability performance in adolescents aged 10–18 years with spastic hemiplegic (n=18) or diplegic (n=13) CP and in their age-matched controls (n=34). The modern difusion-weighted MRI analysis included the difusivity properties of seven CC subparts and the transcallosal lower limb sensorimotor tract of the dominant hemisphere. Children with CP had comprehensive impairments in the cross-sectional area, fractional anisotropy, and mean difusivity of the CC and sensorimotor tract. Additionally, the extent of WM alterations varied between hemiplegic and diplegic subgroups, which was seen especially in the fractional anisotropy values along the sensorimotor tract. The difusion properties of transcallosal WM were further associated with static stability in all groups, and with dynamic stability in healthy controls. Our novel results clarify the mechanistic role of the corpus callosum in adolescents with and without CP ofering valuable insight into the complex interplay between the brain’s WM organization and motor performance. A better understanding of the brain basis of weakened stability performance could, in addition, improve the specifcity of clinical diagnosis and targeted rehabilitation in CP.peerReviewe

Limb-specific thalamocortical tracts are impaired differently in hemiplegic and diplegic subtypes of cerebral palsy

Thalamocortical pathways are considered crucial in the sensorimotor functioning of children with cerebral palsy (CP). However, previous research has been limited by non-specific tractography seeding and the lack of comparison between different CP subtypes. We compared limb-specific thalamocortical tracts between children with hemiplegic (HP, N = 15) or diplegic (DP, N = 10) CP and typically developed peers (N = 19). The cortical seed-points for the upper and lower extremities were selected (i) manually based on anatomical landmarks or (ii) using functional magnetic resonance imaging (fMRI) activations following proprioceptive-limb stimulation. Correlations were investigated between tract structure (mean diffusivity, MD; fractional anisotropy, FA; apparent fiber density, AFD) and sensorimotor performance (hand skill and postural stability). Compared to controls, our results revealed increased MD in both upper and lower limb thalamocortical tracts in the non-dominant hemisphere in HP and bilaterally in DP subgroup. MD was strongly lateralized in participants with hemiplegia, while AFD seemed lateralized only in controls. fMRI-based tractography results were comparable. The correlation analysis indicated an association between the white matter structure and sensorimotor performance. These findings suggest distinct impairment of functionally relevant thalamocortical pathways in HP and DP subtypes. Thus, the organization of thalamocortical white matter tracts may offer valuable guidance for targeted, life-long rehabilitation in children with CP.peerReviewe